Imetelstat-mediated alterations in fatty acid metabolism to induce ferroptosis as

a therapeutic strategy for acute myeloid leukemia .         

Nat Cancer (2023) 

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📌Significance :

They develop an AML patient-derived xenograft resource and perform integrated genomics,

transcriptomics and lipidomics analyses combined with functional genetics to identify key mediators

of imetelstat efficacy.

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📌Importance of lipidology :

The paper shows that imetelstat affects FASD2 & ACSL4 that are related to polyunsaturated fatty

acids (PUFAs) and lipid peroxidation. It reports PUFAs and lipid peroxidation are the reason ferroptosis

occurs in AML cells through Imetelstat.

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📌Connectivity to other fields :

The telomerase inhibitor for myelodysplastic syndrome therapy, now discovered to exhibited novel

mechanism in AML.

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https://doi.org/10.1038/s43018-023-00653-5