Cultured macrophages transfer surplus cholesterol into adjacent cells in

the absence of serum or high-density lipoproteins .        

Journal: PNAS, 2020; 117 (19) 10476-10483

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📌Significance :

Cholesterol efflux on macrophage is an important physiological process. In this study, authors found

macrophages unload cholesterol directly into adjacent smooth muscle cells.

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📌Importance of lipidology :

This study provides a mechanism for cholesterol efflux of macrophage.

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📌Connectivity to other fields :

For define and visualize the cholesterol efflux on macrophage, NanoSIMS imaging was used in this study.

The accuracy of NanoSIMS can provide more precise results for tracking cholesterol efflux.

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https://www.pnas.org/doi/suppl/10.1073/pnas.1922879117