Apolipoprotein M/sphingosine 1-phosphate protects against diabetic

nephropathy.

Transl Res. 2023 Aug:258:16-34.

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📌Significance :

ApoM with Sphingosine 1-phosphate (S1P) in HDL metabolism and their roles play in kidney disease were evaluated. This study discovered that serum ApoM levels inversely related to clinical stages of diabetic nephropathy in type 2 diabetic patients.

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📌Importance of lipidology :

Collateral effective of ApoM and S1P involved in the process of kidney inflammation.

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📌Connectivity to other field :

Cellular physiological understand of ApoM and particular lipid metabolite, which considered as inflammationmediator, in kindey cell pathogenesis.

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https://pubmed.ncbi.nlm.nih.gov/36805561/