Cancer cells depend on environmental lipids for proliferation when electron 

acceptors are limited.

Journal: Nature Metabolism, 4, pages 711–723 (2022)

.

📌Significance :

De novo lipid biosynthesis can impose a substantial NAD+ consumption cost in proliferating cancer

cells. This study revealed NAD+ availability controls the rate of lipid biosynthesis.

.

📌Importance of lipidology :

This study defined a requirement for oxidative metabolism to support biosynthetic reactions and

provide a mechanistic explanation for cancer cell dependence on lipid uptake in electron

acceptor-limited conditions.

.

📌Connectivity to other fields :

Computational prediction of the NAD+ consumption costs associated with synthesis of biomass

components.

-

✏️READ MORE

https://www.nature.com/articles/s42255-022-00588-8